Curation Information

Publication

Characterization of the ArsRS regulon of Helicobacter pylori, involved in acid adaptation.;Pflock M, Finsterer N, Joseph B, Mollenkopf H, Meyer TF, Beier D;Journal of bacteriology 2006 May; 188(10):3449-62 [16672598]

TF

ArsR [O24973, view regulon]

Reported TF sp.

Helicobacter pylori 26695

Reported site sp.

Helicobacter pylori 26695

Created by

Elizabeth Cardosa

Curation notes

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External databases

NCBI GEO (GSE4293) http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE4293.

Experimental Process

DNA-array expression analysis was performed with wild type RNA and mutant ArsS strains to identify helicobactor pylori G27 ureA and ureI are positively regulated by Ars~P. Additionally norhtern blot, Primer extension assay and DNAse footprinting were performed to verify the microarray results.

Transcription Factor Binding Sites

• Sites reported in the paper
• Sites matched in the genome

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.