Curation Information

Publication: The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator.;Gomis-Rüth FX, Solá M, Acebo P, Párraga A, Guasch A, Eritja R, González A, Espinosa M, del Solar G, Coll M;The EMBO journal 1998 Dec 15; 17(24):7404-15 [9857196]
TF: CopG [P13920, view regulon]
Reported TF sp.: Streptococcus agalactiae
Reported site sp.: Streptococcus agalactiae
Created by: Erill Lab
Curation notes: -
External databases: Protein Data Bank (2CPG) .

Experimental Process

Co-complex of RepA/CopG with its DNA operator sequence.

Transcription Factor Binding Sites

Sites reported in the paper
Sites matched in the genome

GATTGCATTGAGTGCACGG

GAATGCATTGAGTGCACGG

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence	Regulated genes	Gene diagram	Experimental techniques	TF function	TF type
GAATGCATTGAGTGCACGG			Experimental technique details X-ray crystallography (ECO:0005670) X-ray crystallography - ECO:0005670 X-ray crystallography is a method to determine the molecular structure of a crystal that is typically used to probe at the tridimensional structure of proteins. In some cases, it is possible to co-crystallize the protein bound to its DNA binding site, providing detail on the particular arrangement of the two components. Doing so provides, obviously, unequivocal evidence of binding. -	repressor	dimer