Curation Information

Publication
CodY-affected transcriptional gene expression of Streptococcus pyogenes during growth in human blood.;Malke H, Ferretti JJ;Journal of medical microbiology 2007 Jun; 56(Pt 6):707-14 [17510253]
TF
CodY [B5XI03, view regulon]
Reported TF sp.
Streptococcus pyogenes NZ131
Reported site sp.
Streptococcus pyogenes NZ131
Created by
Grace Chandler
Curation notes
-

Experimental Process

qRT-PCR using both wild-type and codY mutant strains determined which genes were repressed by CodY. A previously identified 15-bp palindromic CodY binding sequence was used for a BLAST search with an 80% identity match threshold to identify putative CodY binding sites for these 15 genes.

Transcription Factor Binding Sites


AATATTCAGATAATT
AATTTTCAGTCAATT
TAGTTTCAGAAAATA
AATATTCAGAAAATT
AATTTTCTGAAAAAG
AATTTTCTGAAAAAA
GATTTTCTGAAAAAG
ATTTTTCAGAAAATG
AATTATCAGAAAAGA
AATTTTCTGATAATT
GATTTTCTGAAAAAT
ATTTTTCAGAAAATC
TATTTTCTGAAAATA
ATTTTTCTGAAAATG
CATTTTCAGAAAAAT
AATATTCAGATAATT
AATTTTCAGTCAATT
TAGTTTCAGAAAATA
AATATTCAGAAAATT
AATTTTCTGAAAAAG
AATTTTCTGAAAAAA
GATTTTCTGAAAAAG
ATTTTTCAGAAAATG
AATTATCAGAAAAGA
AATTTTCTGATAATT
GATTTTCTGAAAAAT
ATTTTTCAGAAAATC
TATTTTCTGAAAATA
ATTTTTCTGAAAATG
CATTTTCAGAAAAAT

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
AATATTCAGATAATT oppA,
... ... oppA dacA oppB oppC oppD oppF
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATTTTCAGTCAATT braB,
... ... braB Spy49_0272
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
TAGTTTCAGAAAATA Spy49_0540,
... ... Spy49_0540 Spy49_0539c dinG
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATATTCAGAAAATT Spy49_0684
... ... Spy49_0684
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATTTTCTGAAAAAG kup
... ... kup
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATTTTCTGAAAAAA aapA
... ... aapA
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
GATTTTCTGAAAAAG tkt
... ... tkt
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
ATTTTTCAGAAAATG manL,
... ... manL manM manN Spy49_1357
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATTATCAGAAAAGA phaB,
... ... phaB Spy49_1370c fabH acpP
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
AATTTTCTGATAATT codY,
... ... codY Spy49_1386c
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
GATTTTCTGAAAAAT uvrA,
... ... uvrA pepP comEB efp Spy49_1419c nusB Spy49_1424 Spy49_1425
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
ATTTTTCAGAAAATC Spy49_1424,
... ... Spy49_1424 uvrA pepP comEB efp Spy49_1419c nusB Spy49_1425
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
TATTTTCTGAAAATA pgk
... ... pgk
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
ATTTTTCTGAAAATG Spy49_1761c,
... ... Spy49_1761c argS Spy49_1763
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified
CATTTTCAGAAAAAT argS,
... ... argS Spy49_1761c Spy49_1763
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified