Curation Information

Publication

Molecular properties and transcriptional control of the phosphofructokinase and pyruvate kinase genes in a ruminal bacterium, Streptococcus bovis.;Asanuma N, Kanada K, Hino T;Anaerobe 2008 Oct; 14(4):237-41 [18565772]

TF

CcpA [S5RJF3, view regulon]

Reported TF sp.

Streptococcus bovis JB1

Reported site sp.

Streptococcus bovis JB1

Created by

Matthew Coveyou

Curation notes

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Experimental Process

qRT-PCR of a ccpA mutant strain revealed a 40% decrease in pyk gene expression compared to the wild type which suggested the role of CcpA as an activator of pyk. This was further supported by the identification of a CRE site in the pyk-pfk promoter region by visual identification

Transcription Factor Binding Sites

• Sites reported in the paper
• Sites matched in the genome

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.