Curation Information

Publication

Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur.;Ernst FD, Homuth G, Stoof J, Mäder U, Waidner B, Kuipers EJ, Kist M, Kusters JG, Bereswill S, van Vliet AH;Journal of bacteriology 2005 Jun; 187(11):3687-92 [15901691]

TF

Fur [Q1CU85, view regulon]

Reported TF sp.

Helicobacter pylori 26695

Reported site sp.

Helicobacter pylori 26695

Created by

Joe Sparenberg

Curation notes

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Experimental Process

2D PAGE determined that apo-Fur represses sodB and the results were confirmed by MALDI-TOF. EMSA showed that Fur directly binds to sodB with low affinity. DNase I footprinting showed the sequence of the binding site.

Transcription Factor Binding Sites

• Sites reported in the paper
• Sites matched in the genome

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.